Pleural thoracocentesis, or simply thoracentesis, is an important procedure for the drainage of excess fluid or air from the pleural space, the area between the lungs and the chest wall. The process involves the introduction of a needle or catheter through the chest wall into the pleural space to aspirate excess fluid or air that may be causing symptoms like dyspnea. Pleural thoracocentesis is a diagnostic intervention in connection with the examination of fluid for infection, cancer cells, or other abnormalities; also, it is done with therapeutic intentions to relieve symptoms. Normally, this is performed under local anesthesia. Imaging techniques, such as ultrasound, enhance the accuracy of this procedure. This review confirms that proper placement of the needle or catheter reduces complications and increases its effectiveness. In particular, pleural thoracocentesis may immediately relieve symptoms related to the accumulation of fluid or air, significantly improving the quality of life. In addition, it allows aspirated fluid to be used for further diagnosis of the underlying disease and the administration of correct treatment. Generally well-tolerated, it may give patients some discomfort or even temporary side effects amenable to post-procedural care. Pleural thoracocentesis remains an all-time, sure, and effective tool in the management of problems within the pleural space, both diagnostic and therapeutic.